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预制单域抗体库

vwin目前向全球客户展示来自骆驼的多个精心定制的单域抗体(sdab或域抗体)库,llamas as well as humans.We are happy to leverage our unparalleled library resources and extensive expertise to assist our clients with their sdAb 徳赢discovery and development projects.

Single domain antibodies,derived from camelid species,代表一种特殊类型的抗体,由单个单体可变抗体域组成。分子量只有12-15kDa,单域抗体比普通抗体(150-160kDa)小得多。Therefore,单域抗体结合了传统抗体的优点和小分子药物的重要特征,近年来在生物药物开发领域受到越来越多的关注。

单域抗体的优点:

  • Better solubility
  • 能够与隐藏的表位结合,这些表位不能被整个抗体所获取。
  • Greater affinity and selectivity,副作用小,疗效好。
  • 比其他抗体更快地渗透组织,甚至突破血脑屏障
  • Higher stability to changes in temperature and chemical environments,胃肠道稳定和口服的巨大潜力
  • Exceptional drug format flexibility and allow efficient drug 徳赢discovery and development
Premade Single Domain Antibody Library

目前,在创意生物实验室有以下预先制作的SDAB库可供许可:vwin

卡夫HHL-1:骆驼单域抗体库

  1. 噬菌体显示系统
  2. 包含短6xhis和c-myc检测标签的M13 PIII融合
  3. VH骆驼淋巴细胞H抗体基因
  4. 容量:1.5×10
  5. TG1细胞增殖
  6. hb2151中可溶性抗体片段的产生
  7. Helper phage M13K07

卡夫HHL-2:骆驼单域抗体库

  1. 噬菌体显示系统
  2. 包含短6xhis和c-myc检测标签的M13 PIII融合
  3. VH骆驼淋巴细胞H抗体基因
  4. Capacity: 2.0×10
  5. TG1细胞增殖
  6. hb2151中可溶性抗体片段的产生
  7. Helper phage M13K07

LlaVHHL-1: Llama Naïve Single Domain Antibody Library

  1. 噬菌体显示系统
  2. 包含短6xhis和c-myc检测标签的M13 PIII融合
  3. VH骆驼淋巴细胞H抗体基因
  4. Capacity: 2.0×10
  5. TG1细胞增殖
  6. hb2151中可溶性抗体片段的产生
  7. Helper phage M13K07

此外,we also have two HuSdL®Human Single Domain Antibody Libraries that allow rapid 徳赢discovery of large numbers of high-potency camelized human single domain antibodies against any therapeutic targets.与产生骆驼衍生抗体的单域抗体库相比,our library produces camelized human antibodies that have a human origin,考虑到人类最低的免疫原性潜能,especially for long-term and multiple-dose administration.

人单域抗体库

  1. 噬菌体显示系统
  2. 包含短c-myc检测标记的M13 PIII融合
  3. Based on camelized human VH3 in FR2
  4. Enlongated and randomized human HCDR3
  5. 容量:1.5×10
  6. TG1细胞增殖
  7. hb2151中可溶性抗体片段的产生
  8. Helper phage M13K07

人单域抗体库

  1. 噬菌体显示系统
  2. 包含短c-myc检测标记的M13 PIII融合
  3. Based on camelized human VH3 in FR2
  4. Enlongated and randomized human HCDR3
  5. Capacity: 2.5×10
  6. TG1细胞增殖
  7. hb2151中可溶性抗体片段的产生
  8. Helper phage M13K07

The two libraries were preselected based on the thermostability and expressibility (inE.coli)显示的抗体。明确地,在图书馆里,the antibody repertoire was heat-treated to remove clones that could not withstand heat-induced aggregation.The genetic codons used to encode the antibody binders are also optimized for bacterial preference.These libraries are invaluable resources for isolating human single domain antibody binders for research,诊断和治疗应用。

此外,we are also happy to tailor custom-oriented services of sdAb library construction and screening against a variety of targets.我们的技术人员随时准备与您讨论每个具体项目。请随意inquire usfor more information.




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