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Native™抗体发现服务徳赢

Native™ Antibody 徳赢Discovery Service

vwin自豪地开发了独特的native™抗体发现平台,利用抗原特异性B淋巴细胞细胞术技术开发了本地单克隆抗体徳赢。

Currentin vitro抗体显示方法不能提供自然配对的重链和轻链抗体。For technical reasons,在抗体产生B细胞中发现的重链和轻链的自然配对在构建组合库时没有保留。导致在这些系统中VH和VL随机配对德诺沃或者没有人类抗体库。这可能导致抗体分子的产生,这些分子具有次优的溶解性或其他生物物理特性。从而,antibodies derived from these technologies most likely do not represent the naturally cognate heavy and light chains.

Another limitation often observed is that antibody derived fromin vitroantibody display methods generally have moderate affinity to the targets,often in the 1-50 nM KD range,so they often require further affinity maturation before used as potential therapeutics.This is due to a practical limitation to the library size and hence diversity that can be constructed.Phage libraries are restricted to about 10到10十一细菌转化效率及噬菌体实际密度限值10左右的总多样性13/mL.

为了解决这个问题,vwin创新生物实验室开发了独有的Native™抗体发现平台,用于分离单个抗原特异性血浆细胞,以检索具有极高水平的天然抗体。徳赢体内特异性和亲和力。Moreover,这项新技术使我们能够同时选择大量的抗体候选物。此外,选择只需免疫后2-3周。目前为止,它应被认为是从人类身上开发天然单克隆抗体的最有效方法,兔子,胡扯,老鼠,chicken and other species such as camelids,sheep,monkeys,狗甚至牛。For initiating native antibody development,单个B细胞需要分离和鉴定。根据使用的原则,the existing techniques can be classified into two groups,一种基于细胞物理特性,另一种基于细胞生物学特性。

天然抗体开发中单细胞分离的主要方法:


Mammalian Protein-Protein Interaction Trap (MAPPIT) Service图1。Some single cell isolation technologies (Ping Hu,et al.2016)

我们的Native™抗体发现服务的优势包括但不限于:徳赢


可用于开发天然抗体的多种物种

作为抗体发现和制造领域的先驱和无可争议的全球领导者,徳赢vwinoffers native monoclonal antibodies for both academic and clinical use.Our highly professional scientists are confident in providing the domestic and international customers with the best possible services while at the most competitive price.




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